A single-dose interaction study with zolpidem tartrate 10 mg and fluoxetine 20 mg at steady-state levels in male volunteers failed to demonstrate any clinically significant pharmacokinetic or pharmacodynamic interactions. When multiple doses of zolpidem and fluoxetine were given at steady state along with the concentrations evaluated in healthy females, an increase in the zolpidem half-life (17%) was observed. There was no proof of an additive effect in psychomotor performance.

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